ARA290 is an EPO derivative that is a specific agonist of CD131 heteroreceptor, commonly used in the treatment of neurological diseases.
After transplanting ECFC into mice using CLI, a single injection of ARA290 enhanced the ischemic/non ischemic ratio of hind limb blood flow and capillary density after 28 days, as well as the homing of radiolabeled transplanted cells to ischemic legs 4 hours after transplantation . ARA290 (30 μ G/kg, sc) can prevent progressive deterioration of glucose control without affecting the weight of rats. ARA290 significantly reduces glucose AUC in IPGTT of GK rats Low dose ARA290 (35 μ The treatment with g/kg and ip only slightly reduced the severity of EAE in rats. ARA290 treatment group (70 μ G/kg, intraperitoneal injection) significantly delays seizures, reduces neurological severity, and shortens the duration of EAE in a dose-dependent manner.
Diabetes Goto Kakizaki (GK) rats derived from Wistar rats reproduce in our department. Normal Wistar (W) rats were used as non diabetes control. All animals are approximately 6 weeks old and weigh between 100 and 150g when treatment begins. Keep them at 22 ° C, reverse the 12 hour dark cycle, and have free access to food unless fasting overnight as described below. Administer once daily subcutaneous (SC) injection for 30 days μ Rats were treated with ARA290 for more than 4 weeks at a dose of g/kg body weight or PBS. Collect blood samples for measuring glucose after the small tail incision and analyze weekly before subcutaneous injection of ARA290 or placebo in the morning. During the experiment, weight was
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